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The Salk Institute for Biological Studies is well on the way to abolishing exercise. They've managed to simultaneously boost both endurance and weight-gain resistance in sedentary mice by permanaently activating the genetic switch "PPAR delta". Could this be an efficient, effective way to stave of obesity and it's associated side-effects in the future?

Mice were given "GM1516", and "AICAR". "GM1516" activates (or emulate activation of) the PPAR delta gene, and "AICAR" to activate "AMPK", a metabolic master regulator (to emulate exercise).